Research
One of the cornerstones of the development of herbal extracts at Herrens Mark is research. REGOROS is a product that stems from the collaboration between researchers and our company. Research has thus become part of Herrens Mark’s DNA..
In the coming years, Herrens Mark will continue to develop new and innovative extracts with scientifically proven effect. We will do so in collaboration with researchers and developers around the world. Some of the research that has already been published is available online and is described below.
Two groundbreaking research findings form the basis of Herrens Mark’s Food for Special Medical Purposes – REGOROS
In two major patient trials from Aarhus University Hospital, Denmark, Associate Professor PhD Per Bendix Jeppesen and MSc Max Lambert have documented the effect of fermented red clover extract from Herrens Mark.
The first patient trial documented fewer hot flushes and the prevention of osteoporosis with Fermented Red Clover Extract from Herrens Mark
The first patient trial (60 women with severe menopausal symptoms)
A clearly beneficial effect on hot flushes was seen in the treated group
- An average reduction in the amount of sweat of 40%
- An average decrease in the number of hot flushes by approximately 23%
- Total stoppage of bone decalcification over 3 months (measured in the spine by DXA scan) = formed the basis of patient trial no. 2
Patient trial 1 has been published in the scientific journals:
PLOS One: https://doi.org/10.1371/journal.pone.0176590
Hindawi: https://doi.org/10.1155/2015/689138
Or read more at videnskab.dk: Link
Example of a 24-hour data set for skin conductance showing baseline (top) and after 12 weeks of treatment with red clover (bottom). Skin conductance is an indication of the amount of sweat, as moisture increases the skin’s conductance level.
The second patient trial documented the prevention of osteoporosis with fermented red clover extract from Herrens Mark
The second patient trial (two groups of women, all with osteopenia – the precursor to osteoporosis)
All women in this study were tested over the course of one year. A surprising effect on the decalcification of bones was seen in the treated group.
- The placebo group lost 3% of their bone mass during the year
- Scans of the treated group showed a total stoppage of bone loss after one year (measured via DXA scan of the spine and hip)
Patient trial no. 2 has been published in the scientific journal:
The American Journal of Clinical Nutrition: https://doi.org/10.3945/ajcn.117.153353
For further information, please visit Videnskab.dk: Link
The average change in bone mineral density (BMD) between the control and the red clover group in measurements of L2-L4 (lumbar vertebrae), FN (femoral neck) and trochanter (hip).
Major international meta-analysis documents that only fermented red clover has a bone-preserving effect
A major international meta-analysis conducted by Aarhus University Hospital clearly showed that isoflavones must undergo a fermentation process in order to have a beneficial effect on osteopenia and decalcification of bones in women before, during and after menopause.
Isoflavones are initially naturally bound to sugar. During the fermentation process, the sugar molecules are separated, allowing the isoflavones to be absorbed directly into the bloodstream.
The only red clover product on the market to have undergone this special fermentation process is the Fermented Red Clover Extract from Herrens Mark.
The meta-analysis has been published in the scientific journal:
The American Journal of Clinical Nutrition
The American Journal of Clinical Nutrition: https://doi.org/10.3945/ajcn.116.151464
Sources
- Kanis JA on behalf of the World Health Organization Scientific Group. (2007): “Assessment of osteoporosis at the primary health-care level”. World Health Organization Collaborating Centre for Metabolic Bone Diseases.
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Lambert, Max Norman Tandrup; Meng Hu, Lin; Jeppesen, Per Bendix (2017: „A systematic review and meta-analysis of the effects of isoflavone formulations against estrogen-deficient bone resporption in peri- and postmenopausal women. The American Journal of Clinical Nutrition, pp.801-811. American Society for Nutrition.